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KMID : 0895420130230020065
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Journal of Korean Society of Occupational and Enviromental Hygiene
2013 Volume.23 No. 2 p.65 ~ p.74
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Analysis of Trace Level and Correlation of Lead in the Plasma of Field Workers and General Public by ICP-MS
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Lee Sung-Bae
Yang Jeong-Sun
Choi Sung-Bong
Kim Nam-Soo
Lee Byung-Kook
Shin Ho-Sang
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Abstract
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Objectives: This study attempted to develop a method to measure ultra-trace lead concentrations in plasma using Inductively Coupled Plasma Mass Spectrometry(ICP-MS) and to test whether plasma lead can be used as a biomarker for the biological monitoring of exposure to lead.
Methods: Lead concentrations in 160 plasma samples of field workers and 42 plasma samples from the control group were measured by ICP-MS. Blood zinc protophorphyrin(ZPP) concentrations and urinary δ-aminolevulinic acid(δ-ALA) were measured for correlation analysis with plasma lead.
Results: The mean lead level in the plasma of the workers exposed to lead at work were 786.1 ng/L. Plasma lead levels were not correlated with blood ZPP or urinary δ-ALA concentrations. Otherwise, plasma lead levels showed a good correlation coefficient of 0.400 with blood lead levels, and their correlation coefficient had a better value of 0.552 for the non-smoking and drinking group. In the general population group which was not exposed to lead in the workplace and was considered the control group, the mean concentration of plasma lead was 123.1 ng/L. The plasma lead levels for the general population group showed a good correlation coefficient of 0.520 with blood ZPP and urinary δ-ALA concentrations.
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KEYWORD
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ICP-MS, lead, plasma, biomarker
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